DigeZyme® – what is it and why is it used in dietary supplements?

DigeZyme® is a patented multi-enzyme complex developed by Sabinsa Corporation. It contains a combination of five digestive enzymes that together support the breakdown of protein, carbohydrates, fats, lactose, and cellulose.

But why are digestive enzymes relevant in a dietary supplement? And why does Skytrition choose to include DigeZyme® in GuardUP, IsoUP, and WheyUP?

Here, we walk you through everything you need to know.

What is DigeZyme®?

DigeZyme® is a patented and standardized multi-enzyme complex from Sabinsa Corporation. It contains five specific enzymes:

• Amylase – breaks down carbohydrates and starch
• Protease – breaks down proteins into amino acids and peptides
• Lipase – breaks down fats into fatty acids and glycerol
• Lactase – breaks down lactose (milk sugar)
• Cellulase – breaks down cellulose from plant-based foods

Together, these five enzymes cover the breakdown of the most important macronutrients, making DigeZyme® broad-spectrum digestive support.

How do digestive enzymes work?

Digestive enzymes are proteins that catalyze chemical reactions in the digestive system. They help the body break down food into smaller components that can be absorbed through the intestinal wall.

The body produces its own digestive enzymes—in the mouth, stomach, pancreas, and small intestine. However, in cases of high protein intake, stress, aging, or a sensitive stomach, natural enzyme production may be insufficient to optimally break down all food.

That is where an external enzyme supplement like DigeZyme® can play a role.

Why is DigeZyme® relevant in protein products?

When you consume large amounts of protein—such as in a protein powder—the body needs to break it down into amino acids in order to absorb it. The protease enzyme in DigeZyme® supports this process.

For people who are sensitive to lactose, the lactase enzyme is particularly relevant—it helps break down the milk sugar in whey protein, which can reduce the risk of stomach discomfort.

The combination of enzymes makes DigeZyme® broad-spectrum digestive support that fits well into protein products where the goal is maximum absorption and minimal stomach impact.

DigeZyme® compared to other digestive enzymes

There are many digestive enzymes on the market. What makes DigeZyme® unique is:

• Patented and standardized formula – consistent enzyme activity per dose
• Five enzymes in one – covers protein, carbohydrates, fats, lactose, and cellulose
• Developed by Sabinsa – an established ingredient company with a long history in dietary supplements
• Common in premium protein products – used by leading brands globally

When is the best time to take DigeZyme®?

Since DigeZyme® is included in protein products, it is naturally taken in connection with meals or protein intake:

• With a protein shake – to support the breakdown of the protein
• After training – when the need for protein is high and rapid absorption is desired
• With high-protein meals – as general digestive support

In which Skytrition products is DigeZyme® found?

DigeZyme® is used in three of Skytrition’s protein products:

• GuardUP – Skytrition’s slow-release casein protein, with DigeZyme® for optimal protein uptake overnight or between meals
• IsoUP – an isolate-based whey protein with DigeZyme® for rapid and efficient absorption
• WheyUP – a concentrate-based whey protein with DigeZyme® for broad digestive support

What should you consider when choosing products with DigeZyme®?

1. The dose of DigeZyme®

Check how much DigeZyme® is included per dose. A clear ingredient list should specify the amount and the enzyme activity separately.

2. Lactose intolerance

If you are sensitive to lactose, the lactase enzyme in DigeZyme® is particularly valuable. Feel free to combine it with an isolate protein (like IsoUP) for the lowest possible lactose content.

3. Protein type and absorption speed

DigeZyme® works in combination with both fast (whey) and slow (casein) proteins. Choose a product based on your goal – rapid absorption after training or slow release overnight.

Frequently asked questions about DigeZyme®

What is DigeZyme®?
DigeZyme® is a patented multi-enzyme complex from Sabinsa Corporation with five digestive enzymes: amylase, protease, lipase, lactase, and cellulase.

Why is DigeZyme® used in protein powder?
DigeZyme® supports the breakdown of protein into amino acids and can help reduce stomach discomfort, especially with high protein intake or lactose intolerance.

Does DigeZyme® help with lactose intolerance?
The lactase enzyme in DigeZyme® helps break down lactose. However, it is not a medicine for lactose intolerance – consult a doctor regarding severe symptoms.

In which Skytrition products is DigeZyme® found?
DigeZyme® is included in GuardUP, IsoUP, and WheyUP.

Is DigeZyme® safe?
Yes, DigeZyme® is a well-established ingredient from Sabinsa Corporation that has been used in dietary supplements globally for many years.

Summary

DigeZyme® is a patented multi-enzyme complex with five enzymes that support the breakdown of protein, carbohydrates, fats, lactose, and cellulose. It is used in Skytrition’s GuardUP, IsoUP, and WheyUP to support protein uptake and reduce the risk of stomach discomfort.

When choosing protein products with DigeZyme® – look at the dose, the protein type, and whether you are sensitive to lactose.

More ingredient guides

Do you want to read more about other patented ingredients in Skytrition’s products?

• AstraGin® – the absorption enhancer that helps the body take up nutrients better
• CocoMineral® – natural electrolytes from coconut water
• GlycerSize™ – highly concentrated glycerol for pump and hydration
• PerforMelon® – natural citrulline and electrolytes from watermelon