S7® – what is it and why is it used in dietary supplements?
S7® is a patented complex of seven plant extracts used in dietary supplements to increase the body's own nitric oxide (NO) production. It is developed by FutureCeuticals and is clinically studied with a documented ability to increase endogenous nitric oxide by up to 230%.
But what is nitric oxide and why is it so important for training performance? And why does Skytrition choose to use S7® in MessitUP and BlowitUP?
Here we walk you through everything you need to know.
What is S7®?
S7® is a patented and standardized complex of seven plant extracts, developed by FutureCeuticals in the USA. The seven plant extracts are:
- Green coffee bean (Coffea arabica)
- Green tea (Camellia sinensis)
- Turmeric (Curcuma longa)
- Tart cherry (Prunus cerasus)
- Blueberry (Vaccinium angustifolium)
- Broccoli (Brassica oleracea)
- Kale (Brassica oleracea var. sabellica)
Together, these seven extracts form a synergistic complex with a documented ability to stimulate the body's own nitric oxide production.
What is nitric oxide and why is it important?
Nitric oxide (NO) is a signaling molecule produced naturally in the body. It plays a central role in widening blood vessels (vasodilation), which increases blood flow to the muscles.
Increased blood flow to the muscles means:
- Increased oxygen supply – muscles receive more oxygen during exercise
- Better nutrient transport – amino acids and glucose are delivered more efficiently
- Pump effect – muscles swell and feel harder during training
- Faster recovery – better removal of metabolites such as lactic acid
How does S7® work?

The unique thing about S7® is that it does not provide nitric oxide from the outside – instead, it stimulates the body's own nitric oxide production via the enzyme eNOS (endothelial nitric oxide synthase).
Clinical studies show that S7® increases endogenous nitric oxide by up to 230% compared to placebo – at a dose of as little as 50 mg.

This makes S7® one of the most effective and dose-efficient nitric oxide ingredients on the market.
S7® compared to other NO ingredients
- vs. L-citrulline – S7® acts via a different mechanism (eNOS activation) and can be combined with citrulline for a synergistic effect
- vs. L-arginine – S7® has better bioavailability and acts at a lower dose
- vs. Beetroot – S7® is more concentrated and standardized for consistent effect

When is the best time to take S7®?
- Before training – 30–45 minutes before for maximum pump and blood flow effect during the session
- In pre-workout formulas – preferably combined with L-citrulline and other NO ingredients for a synergistic effect
In which Skytrition products is S7® found?
S7® is used in:
- MessitUP – Skytrition's pre-workout with S7® for maximum pump and blood flow
- BlowitUP – includes S7® for increased nitric oxide production and pump
What to consider when choosing products with S7®?
1. The dose of S7®
The clinically studied dose is 50 mg. Check that the product contains at least this amount for a documented effect.
2. Combination with citrulline
S7® is often combined with L-citrulline or citrulline malate for a synergistic NO effect. Look at the entire NO matrix in the product.
3. Timing of intake
Take the S7® product 30–45 minutes before training for optimal effect during the session.
Frequently asked questions about S7®
What is S7®?
S7® is a patented complex of seven plant extracts from FutureCeuticals, clinically studied for its ability to increase endogenous nitric oxide by up to 230%.
How much does S7® increase nitric oxide?
Clinical studies show that S7® increases endogenous nitric oxide by up to 230% compared to placebo at a 50 mg dose.
Can S7® be combined with citrulline?
Yes, S7® and citrulline act via different mechanisms and can be combined for a synergistic NO effect.
In which Skytrition products is S7® found?
S7® is included in MessitUP and BlowitUP.
Is S7® natural?
Yes, S7® is a complex of seven natural plant extracts.
Summary
S7® is a patented complex of seven plant extracts with a documented ability to increase the body's own nitric oxide production by up to 230%. It works via eNOS activation and delivers a pump, increased blood flow, and better oxygen supply to the muscles.
It is used in Skytrition's MessitUP and BlowitUP for maximum pump and performance support.
More ingredient guides
- Zynamite® – mango leaf extract for energy and focus in MessitUP
- GlycerSize™ – high-concentrated glycerol for pump and hydration
- AstraGin® – the absorption enhancer that helps the body absorb nutrients better
- PerforMelon® – natural citrulline and electrolytes from watermelon