BioPerine® – what is it and why is it used in dietary supplements?
You can take the best dietary supplement in the world – but if your body cannot absorb it, it doesn't matter. That is where BioPerine® comes in. A small but crucial ingredient that ensures every active substance actually reaches where it is supposed to.
BioPerine® is found in VitalUP, MultiUP and AmpitUP from Skytrition – and in this guide, we explain exactly why.
What is BioPerine®?
BioPerine® is a registered trademark of Sabinsa Corporation and is a standardized extract of black pepper (Piper nigrum) with at least 95% piperine – the active substance in black pepper. It is one of the most well-studied and widely used bioavailability enhancers in the supplement industry, backed by over 20 clinical studies.
How does BioPerine® work?
Piperine works in several ways to increase the body's ability to absorb nutrients:
- 🔥 Inhibits metabolic enzymes – reduces the rate at which the body breaks down active substances in the liver and gut
- 📦 Increases intestinal permeability – makes it easier for nutrients to pass through the intestinal wall
- ⚡ Stimulates transport proteins – activates mechanisms that transport nutrients into the bloodstream
- 🔁 Extends exposure time – keeps substances in the body longer so they have time to be absorbed
The result? The same dose of an active ingredient can provide significantly higher blood levels when combined with BioPerine®.
What does the research say?
BioPerine® is one of the most documented bioavailability enhancers on the market. Clinical studies have shown that piperine can increase the bioavailability of:
- ✅ Curcumin – by up to 2,000%
- ✅ Coenzyme Q10 – significantly increased absorption
- ✅ B vitamins – incl. B6, B12, and folate
- ✅ Selenium – improved cellular uptake
- ✅ Fat-soluble vitamins – A, D, E, and K
Why is BioPerine® special compared to regular black pepper?
Regular black pepper contains piperine, but in varying amounts and without quality control. BioPerine® is standardized to exactly 95% piperine, which guarantees consistent effect in every dose. It is also clinically tested in this standardized form – something regular black pepper is not.
BioPerine® in Skytrition's products
Skytrition uses BioPerine® in three of its products:
🟢 VitalUP – Liver & Kidney Support
In VitalUP, BioPerine® is combined with OPITAC™ (glutathione), NAC, CurcuPrime®, and several powerful plant extracts. BioPerine® ensures that the glutathione and the other active ingredients are absorbed maximally.
🟢 MultiUP – Comprehensive Multivitamin
In MultiUP, BioPerine® helps the body absorb fat-soluble vitamins (D3, K2, A, E), CoQ10, and B vitamins more effectively. A multivitamin is only as good as what the body actually absorbs.
🟢 AmpitUP – Stim & Nootropic
In AmpitUP, BioPerine® optimizes the absorption of the nootropic ingredients – citicoline, L-tyrosine, Zynamite®, and EnExtra® – so you get the most out of every pre-workout dose.
Is BioPerine® safe?
Yes. BioPerine® is GRAS-classified (Generally Recognized As Safe) by the US FDA and has been used in dietary supplements for over 30 years with no known side effects at recommended doses (2.5–5 mg/day). It is well-tolerated by the vast majority.
NOTE: Piperine can affect how the body metabolizes certain medications. Consult a physician if you are taking prescription medication.
Summary
- ✅ BioPerine® is a patented black pepper extract from Sabinsa Corporation
- ✅ Standardized to 95% piperine for consistent effect
- ✅ Increases the bioavailability of vitamins, minerals, and other active substances
- ✅ Clinically studied in over 20 studies
- ✅ Found in VitalUP, MultiUP, and AmpitUP from Skytrition
- ✅ Safe and well-tolerated at recommended doses
→ Explore VitalUP – Liver & Kidney Support
→ Explore MultiUP – Comprehensive Multivitamin
→ Explore AmpitUP – Stim & Nootropic
Read more about other patented ingredients in Skytrition's range: OPITAC™ – the body's master antioxidant, and Spectra® – over 30 fruit and vegetable extracts in one.
